Cic edizioni internazionali
Giornale Italiano di ostetricia e ginecologia

Serum Lactate Dehydrogenase (LDH) as an indicator of severity in preeclampsia

Original Article, 102 - 107
Tag this article
Full text PDF
Background. Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality. Lactate dehydrogenase levels are usually elevated in this condition and hence measuring LDH levels will help in identification of preeclampsia.
Objectives. To study the correlation of Lactate dehydrogenase levels with maternal and perinatal outcome in preeclampsia and to assess the severity of disease in association with LDH levels. Study Design. Prospective comparative study.
Material and methods. Pregnant women diagnosed with preeclampsia were enrolled in the study conducted at hospitals attached to Kasturba Medical College, Mangalore from September 2015 to March 2017 after approval from the institutional ethical committee.
Serum LDH levels were measured and the women were categorized based on its levels and they were monitored till delivery. Maternal and perinatal outcomes and severity of disease were analyzed according to the levels of serum LDH.
Results. A total of 90 patients with preeclampsia was studied. Mean LDH levels were found to be 646.95 IU/l. In mild preeclamptic women, LDH levels were < 600IU/L. In severe preeclampsia, 20 (44.25%) had LDH levels 800 IU/l. Higher LDH suggested increase
in severity of disease which was found to be statistically significant. LDH was more than 600IU/L in 32(71%) of women with Systolic BP>160 mmHg and 14(31%) of women with Diastolic BP >110 mmHg. There was a significant association between serum LDH
levels and fetal growth restriction, intra uterine fetal demise, low birth weight and low APGAR scores in neonates. Abruption placentae, Eclampsia and disseminated intravascular coagulation were associated with LDH >800IU/L.
Conclusion. Preeclampsia is one of the most common causes for maternal and perinatal morbidity and mortality. Lactate Dehydrogenase (LDH) is a good indicator in assessing the severity in preeclampsia and also can help in early diagnosis and treatment and reducing the complications in mother and fetus.
What is new in this Paper? Preeclampsia is a condition which is difficult to diagnose. Serum markers like Lactate dehydrogenase levels are usually elevated in preeclamptic women. In our study, we found that higher levels of LDH are associated with complications
like abruption, eclampsia and DIC and perinatal morbidity.

Vol. XLI (No. 1) 2019 Gennaio - Marzo

  1. First trimester screening for preeclampsia
    Fichera N., Maugeri G.C., Leanza G., Leanza V., Palumbo M.
  2. Ultrasonic assessment of gestational age by measurement of fetal kidney length in third trimester
    Mahale N.A., Devi A., Mahale A., Ullal S., Fernandes M., Prabhu S.
  3. Expressions of CD 56 + CD 16 + peripheral natural killer (pNK) cells in early idiopathic recurrent miscarriage
    Lintang L.S., Siregar M.F.G
  4. The role of placental growth factor, soluble-Fms-like tyrosine kinase-1 and diastolic notch uterine artery to predict the early onset of preeclampsia
    Lubis M.P., Hariman H., Lumbanraja S.N., Bachtiar A.
  5. A risk-stratified approach to labour and delivery in HIV-infected women in a large tertiary Hospital in the North of Italy
    Palmeri A., Gerbaldo D., Riccardi N., Taramasso L., Del Puente F., Ferraioli D., Di Biagio A.
  6. A perineal lesion miming a sexual abuse in a pre-pubertal girl hit by a low speed motor vehicle
    Franceschetto L., Suadoni F., Lancia M., Cirocchi R., Bacci M., Carlini L.
  7. Assessment on fetal renal volume and function in normal and growth restricted fetuses
    Sitepu M., Haryono Roeshadi R., Siddik D., Prasmusinto D.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Serum Lactate Dehydrogenase (LDH) as an indicator of severity in preeclampsia
    Kittur A.A., Shetty S.K.