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Giornale Italiano di ostetricia e ginecologia

Serum prokineticin-1 (endocrine gland vascular endothelial growth factor) as an alternative marker for assessing endometrium receptivity

Original Article, 158 - 164
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Abstract
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Backgrounds. A total of ± 85-90% fertile couple will be able to conceive within one year. However, if there is no pregnancy within this period, even though the conjugal relationship is carried out regularly and without the use of contraception, a case of primary infertility occurs.
Endometrium receptivity plays an important role in implantation process of conception product, and an optimal understanding about its function is crucial in infertility management.
Purpose. The purpose of this study was to determine the relationship between serum levels of PROK1 (EG-VEGF) to the expression of αvβ3 integrins in endometrial tissue to assess endometrial receptivity of fertile women with normal menstrual cycles.
Method. This study used a cross-sectional study design. This study was conducted in the outpatient unit of the Fertility and Reproductive Endocrinology Division (FER) of the Central General Hospital (RSUP) Dr. H. Adam Malik Medan, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Sumatera Utara and Adenin Adenan Hospital Medan, starting in February 2017.
Result. 42 samples were obtained in this study, with the majority of them came from age group of 20-35 years with 38 subjects (90.5%), normoweight BMI with 31 subjects (73.8%), age of menarche more at age <13 years with 28 subjects (66.7%), and the duration of menstruation for 3-7 days with 40 subjects (95.2%). There were no significant differences in αvβ3 integrin expression based on age, BMI, age of menarche and duration of menstruation (p> 0.05). There were no significant differences in PROK-1 levels based on age, BMI, age of menarche and duration of menstruation (p> 0.05). There was a significant correlation between integrin expression of αvβ3 and PROK1 (EG-VEGF) with a value (p <0.001, r = 0.526).
Conclusion. There is no significant difference in the expression of PROK1 based on age, BMI, age of menarche and duration of menstruation but there is a significant correlation between PROK1 (EGVEGF) serum level and integrin αvβ3 in fertile women.

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