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Giornale Italiano di ostetricia e ginecologia

Association between the ratio of matrix metallo proteinase-2 (MMP-2) to tissue inhibitor of MMP-2 (TIMP-2) level and the expression of collagen type-III in endopelvic fascia of menopausal women with pelvic organ prolapse

Original Article, 165 - 171
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Abstract
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Objective. Pelvic organ prolapse (POP) is one of the most disturbing conditions reported by menopausal women. It has been understood that the balance of MMP-2 and TIMP-2 level play an important role in degradation of collagen type-III in endopelvic fascia which is known as underlying mechanism of POP. This study aimed to investigate the association between ratio of MMP-2 to TIMP-2 level and the expression of collagen type-III in endopelvic fascia of menopausal women with POP.
Method. This was a case-control study involved menopausal women who visited Urogynecology unit of Department of Obstetric and Gynecology, Adam Malik General Hospital from July 2017 to the date till the number of minimal sample was achieved. MMP-2 and
TIMP-2 level and the expression of collagen type-III were measured from biopsy specimen taken during hysterectomy and also from blood serum.
Result. We recruited 45 menopausal women with POP as case group and 47 menopausal women without POP as control group. The mean of ratio of MMP-2 to TIMP-2 level in case group (1,53) was higher than control group (1,02). There was negative correlation between the ratio of MMP-2 to TIMP-2 level and the expression of collagen type-III with r value = 0,638 (close to 0).
Conclusion. This study found that higher ratio of MMP-2 to TIMP-2 level was associated with lower expression of collagen type- III in fascia endopelvic of menopausal women.

Vol. XL (No. 4) 2018 Ottobre - Dicembre

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