Cic edizioni internazionali
Giornale Italiano di ostetricia e ginecologia

Difference in expression of 17 beta-hydroxysteroid dehydrogenase type 1 in uterine fibroid and normal myometrium

Clinical Case, 172 - 177
Tag this article
Abstract
Full text PDF
Background. Uterine fibroid is a gynecological problem that frequently occurs to women in reproductive age. Based on World Health Organization (WHO), in 2010, uterine fibroid was estimated occurred in approximately 20-25% women worldwide, while in Indonesia, the incidence was 2.39-11.7%. Estrogen is one of the things that takes a role in uterine fibroid development. 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) is a type of 17β-HSD enzyme that most often is associated in estrogen metabolism.
Objective. To determine the difference in expression of 17β-HSD1 enzyme in uterine fibroid and normal myometrium.
Methods. This study is a case control study that was conducted in each 20 tissues of uterine fibroid and normal myometrium of the same uterine that were randomly taken from September to November 2017 in Adam Malik General Hospital. The data were subsequently analyzed using Wilcoxon Signed Rank test.
Results. It was found that patients with obese body mass index, multiparity, and submucous uterine fibroid type were the largest groups in this study. Strongly positive expression was found highest in uterine fibroid group (75%). There is a difference in expression of 17β-HSD1 in uterine fibroid and normal myometrium with p<0.05.
Conclusion. The results of this study demonstrate a statistically significant difference between uterine fibroid and normal myometrium.

Vol. XL (No. 4) 2018 Ottobre - Dicembre

  1. The difference between HE4 expression in urine of women with ovarian cyst and women with normal ovary
    Kumalasari C., Rusda M., Sidabutar E.R., Ardiansyah E., Simanjuntak R.Y., Aldiansyah D.
  2. Serum prokineticin-1 (endocrine gland vascular endothelial growth factor) as an alternative marker for assessing endometrium receptivity
    Adenin I., Lutan D., Tandjung T., Suheimi H.K., Siregar M.F.G
  3. Association between the ratio of matrix metallo proteinase-2 (MMP-2) to tissue inhibitor of MMP-2 (TIMP-2) level and the expression of collagen type-III in endopelvic fascia of menopausal women with pelvic organ prolapse
    Tala M.R.Z., Siregar M.F.G, Akbari Ganie R., Budi Putra I., Hasan Purwa B., Iqbal Pahlevi M., Mutiara E.
  4. Difference in expression of 17 beta-hydroxysteroid dehydrogenase type 1 in uterine fibroid and normal myometrium
    Siregar M.F.G, Arthit T.L., Munthe I.G., Haryono H.L., Sidabutar E., Rivany R.
  5. Proposal of “fertility-sparing” surgery technique for ovarian endometriosis
    Bardi M., Pezzetti G., Laquintana R., Petretto R., Marforio M.G., Chiesa A., Gangarossa G., Augello M.L., Iliakis A., Rosaschino P.
  6. Relationship between the administration of estradiol valerate 2 mg and norgestrel 0.5 mg and cognitive function which assessed with IQCODE on menopausal paramedic at Adam Malik General Hospital Medan
    Utari R.A.D., Siregar M.F.G, Hartono H., Nasution S.A., Rivany R., Haryono H.L.
Last Viewed articles: la lista degli ultimi x visitati.
  1. Difference in expression of 17 beta-hydroxysteroid dehydrogenase type 1 in uterine fibroid and normal myometrium
    Siregar M.F.G, Arthit T.L., Munthe I.G., Haryono H.L., Sidabutar E., Rivany R.
credits