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Giornale Italiano di ostetricia e ginecologia

Relationship between the administration of estradiol valerate 2 mg and norgestrel 0.5 mg and cognitive function which assessed with IQCODE on menopausal paramedic at Adam Malik General Hospital Medan

Methods, Techniques, Drugs, 184 - 189
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Abstract
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Background. Menopause is the cessation of menstruation at least 12 months, begins at the age of 45-50 years and is accompanied by the declined of estrogen and progesterone hormones, causing complaints such as the decline in cognitive function. Hormone replacement therapy such as estradiol valerate and norgestrel can reduce complaints and reduce the risk of dementia.
Objective. To assessed the difference in cognitive function with the administration of estradiol valerate 2 mg and norgestrel 0.5 mg which assessed by IQCODE on menopausal paramedics.
Methods. This study is an experimental quasi research with prepost design conducted in July-December 2017. The study subjects were 40 menopausal paramedics at H. Adam Malik General Hospital and selected by consecutive sampling. Study subjects were asked to fill out the IQCODE questionnaire and will be excluded if the result is improvement and no change. Study subjects were asked to consume estradiol valerate 2 mg and norgestrel 0.5 mg for 3 months then cognitive function will be revalued. Data were analyzed using T-paired test.
Results. Out of the 40 study subjects, 2 had improvement and no change, while the other 2 subjects were excluded due to tachycardia and loss to follow-up. The most often encountered characteristics of study subjects were the 50-59 years group (72.2%), multiparous (91.7%), overweight (63.9%) with duration of menopause for 2 years (36.1%).
The mean score of IQCODE before and after intervention was 3.59 ± 0.26 and 3.18 ± 0.29 and there was a relationship between administering estradiol valerate and norgestrel with cognitive function.
Conclusion. There was a significant association between administering estradiol valerate 2 mg and norgestrel 0.5 mg with cognitive function (p < 0,05).

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