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Giornale Italiano di ostetricia e ginecologia

Expressions of CD 56 + CD 16 + peripheral natural killer (pNK) cells in early idiopathic recurrent miscarriage

Original Article, 14 - 21
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Abstract
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Objective. To determine: 1) Is CD56 + CD16 pNK cells higher in early idiopathic recurrent miscarriages compared to normal patients? 2) Are CD56 + CD16 + pNK cells lower in early idiopathic recurrent miscarriages compared to normal patients? 3) Are there any associations between CD56 + CD16 + pNK cells with early idiopathic recurrent miscarriage? Methods. This study was an observational analytic study with cross sectional design comparing CD56+ CD16+ CD3+ in patients with recurrent early idiopathic miscarriage (case group) with patients who had offspring (control group). This study was conducted at the Department of Obstetrics and Gynecology H. Adam Malik General Hospital Medan and several hospitals network. The study was conducted by taking blood samples in the luteal phase, and CD56 +, CD16 +, and were examined. Data analysis using SPSS computer program. This study was conducted on the approval of the patient and has been approved by the Ethics Committee of University of Sumatera Utara Medical Faculty. Results. The mean score of CD56 + CD16 +% lymph of the early idiopathic recurrent miscarriage group was lower than the control groups’ mean score, but the statistical test results with the Mann-Whitney test showed no significant difference in the CD56 + CD16 +% lymph score of the early idiopathic recurrent miscarriage group with the control group. The mean score of CD56 + CD16 + Abs Count of the recurrent idiopathic early recurrent miscarriage group was lower than the mean score of CD56 + CD16 + Abs Count of the control group, and the statistical test results with the Mann- Whitney test showed no significant difference in CD56 + CD16 + Abs Count values of recurrent idiopathic early recurrence with the control group. The ROC value of serum CD56 + CD16 +% lymph level was 0.63. Cut off point is 7.50 with sensitivity of 82% and specificity of 46%. The ROC value of serum CD16 + CD56 + Abs Count was 0.73. The cut off point was 197.50 with a sensitivity of 82% and a specificity of 64. Conclusion. The score of CD56 + CD16 + cell pNK values were lower in the group of patients with early idiopathic recurrent miscarriage than the control group. CD56 + CD16 + pNK cells have been shown to be associated with early idiopathic recurrent miscarriage.

Vol. XLI (No. 1) 2019 Gennaio - Marzo

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  1. Expressions of CD 56 + CD 16 + peripheral natural killer (pNK) cells in early idiopathic recurrent miscarriage
    Lintang L.S., Siregar M.F.G
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