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Giornale Italiano di ostetricia e ginecologia

The impact of vaginal and endometrial microbiota in women’s fertility: a review of literature

Review, 47 - 57
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Abstract
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The microbiome in health and human disease and its impact on human reproduction is becoming better characterized. The existence of a reproductive microbiota has highlighted the importance of a healthy microbiome in all the steps of reproduction, from gamete
formation, to implantation, to labor, involving all the locations within the reproductive tract. Therefore, pathological shifts of these reproductive tract microbiota may be the cause or consequence of diseased conditions in women’s health. In particular, the endometrial microbiome seems to have an impact on embryo implantation and pregnancy maintenance, as an altered endometrial microbiome, characterized by a low abundance of Lactobacillus, has been associated with implantation failure and pregnancy loss. Endometrium is important to develop a healthy placenta and a physiologic pregnancy, so intrauterine infection can be the cause of reproductive complication. Healthy endometrial environment in ongoing pregnancy is important in both
women undergoing IVF and woman wishing to conceive spontaneously.
Different therapies are being investigated, such as specific probiotic and/or antibiotic therapies, drugs for the reduction of uterine peristalsis, and embryoendometrial synchronization during personalized embryo transfer. However, despite the promising findings reported, none of these options has clearly demonstrated a benefit.

Vol. XLI (No. 2) 2019 Aprile - Giugno

  1. The impact of vaginal and endometrial microbiota in women’s fertility: a review of literature
    Piccioni M.G., Merlino L., Mariani M., Paladini V., Giannini A., Faralli I., Riganelli L., Tabacco S., Colagiovanni V., Di Muzio M., Giancotti A., Di Donato V., Monti M.
  2. Early markers of perinatal cerebral ischemia in newborns
    Remneva O.V., Fadeeva N.I., Yavorskaya S.D., Korenovsky Y.V., Koliado O.V.
  3. Accelerated pregnancy termination increases life expectancy for mothers and neonates in cases of acute fatty liver of pregnancy
    Pribadi A., Sibarani C.N.R., Mose J.C., Hidayat Y.M.
  4. 3-D ultrasound in the study of placental vascularization: application of vocal technique. A case-control study and a review of literature
    Piccioni M.G., Vena F., Del Negro V., D'Ambrosio V., Capone C., Donfrancesco C., Tabacco S., Tibaldi V., Fruci S., Giannini A., Schiavi M.C., Muzii L., Brunelli R., Giancotti A.
  5. Uterine asymptomatic myomas: an overview from diagnosis to treatment
    Di Donato V., Musella A., Bracchi C., Lecce F., Colagiovanni V., Di Pinto A., Santangelo G., Giannini A., Tomao F., Palaia I., Perniola G., Muzii L., Benedetti Panici P.
  6. Detection of twin reversed arterial perfusion sequence at the time of first ultrasound screening and its spontaneous resolution: a case report
    Piccioni M.G., Merlino L., Mariani M., Sassu C., Bracchi C., Tabacco S., Schivi M.C., Giannini A., Palaia I., Muzii L., Giancotti A., Monti M.
  7. Two cases of large retroperitoneal schwannoma treated with minimally invasive surgery: role of the gynecologic oncologist
    Giannini A., Usoro E., May J., Moulla A., Walker J., Benedetti Panici P., Congiu M.A.
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  1. The impact of vaginal and endometrial microbiota in women’s fertility: a review of literature
    Piccioni M.G., Merlino L., Mariani M., Paladini V., Giannini A., Faralli I., Riganelli L., Tabacco S., Colagiovanni V., Di Muzio M., Giancotti A., Di Donato V., Monti M.
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