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Giornale Italiano di ostetricia e ginecologia

Correlation between tumor-infiltrating lymphocytes to pathologic response in locally advanced breast cancer patients who receive neoadjuvant chemotherapy in Haji Adam Malik General Hospital

Mini-Review, 67 - 70
doi: 10.11138/giog/2017.39.2.067
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Background. Tumor infiltrating lymphocyte (TILs) are emerging as biomarkers mediating tumor response to treatments. Earlier studied have provided evidence the level of TILs has prognostic value, particulary in triple negative and human epidermal growth factor receptor-2 positive breast cancer. More over the level of TILs has been associated with treatment outcome in patient undergoing neoadjuvant chemotherapy and strong correlation with pathologic complete response. In this study we analyzed whether changes in tumor infiltrating lymphocytes take place after neoadjuvant therapy and if they correlate with pathologic response to treatment.
Patient and methods. We retrospectively analyzed the specimen slide from Anatomic Pathology Department of H. Adam Malik General Hospital during 2011-2015. We identified 51 patients with the inclusion criteria of this study. The histological sections had already
evaluated by hematoxillin and eosin slides. Its re-assessment with our pathologist for the extent of percentage intratumoral (it) and stromal (str) tumor infiltrating lymphocytes (TILs). The correlation with pathologic response in the tumor after neoadjuvant therapy
was also studied in this patients. Each case was also defined as high TILs or low TILs breast cancer adopting previously validated cutoffs.
Results. From the 51 specimens, mean age was 49.22. The most types of breast cancer histology was invasive ductal breast carcinoma in 49 (96%) patients, and 2 patients (4%) with lobular carcinoma. The frequency of histopathological grading with high TILs:
grade 1 encountered 5 patients, grade 2 was 15 and grade 3 was 3 patients. High TILs that had pathological complete response found in 47,8% patient and 28,8% in low TILs. There is no significant correlation between TILs to pathologic response of patients with
neoadjuvant chemotherapy (P= 0,157).
Conclusions. This research has not been able to prove significant correlation between TILs with pathological response in patient with locally advanced breast cancer who received neoadjuvant chemotherapy but high TILs more likely to have complete response. Further information may prove useful to future biomarker trial.

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  1. Correlation between tumor-infiltrating lymphocytes to pathologic response in locally advanced breast cancer patients who receive neoadjuvant chemotherapy in Haji Adam Malik General Hospital
    Siregar B.K., Jamaluddin S.P., Siburian R.
    doi: 10.11138/giog/2017.39.2.067