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Giornale Italiano di ostetricia e ginecologia

The aromatase expression in uterine mioma tissue

Original Article, 27 - 32
doi: 10.11138/giog/2018.40.1.027
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Aim. The uterine mioma is located within the hyperestrogenic environment.
The determination of aromatase expression is incredibly important to determine the pathogenesis and management.
Method. The Research is analytic (cross-sectional) observation to 24 block pyrroffin with immunohistochemical (IHC) examination to know the difference between aromatase expression of uterine and surround- ing uterine tissues.
Result. Statistically, it’s significantly found the correlation between the aromatase expression towards the distance, the further the distance of miometrium from uterine myoma the lower the expression of aromatase enzyme (r = -0.563; p = 0.00).
Conclusion. the Expression of aromatase in miometrium is around myoma is lower than uterine myoma, because uterine myomas can synthesize the estrogen and it has the localized aromatization in tissues that have cell growth promoting effect.

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