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Giornale Italiano di ostetricia e ginecologia

Morphological and morphometric characteristics of lymphoid structures in the walls of fallopian tubes in postnatal ontogenesis

Original Article, 42 - 47
doi: 10.11138/giog/2018.40.1.042
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The urgency of the investigated issue is caused by the problem of female infertility, in which the leading cause is the tubal peritoneal factor (the frequency of which does not tend to decrease), as well as inflammatory diseases of the uterine appendages, which lead to the formation of peritubar adhesions and occlusions of the fallopian tubes. Therefore, at present the fallopian tube is considered as one of the important structures in the female reproductive system. The article is aimed at studying the issues of lymphoid structures anatomy in the walls of the fallopian tubes in postnatal ontogenesis.
One of the approaches to investigating this problem is the immunohistological method which makes it possible to reveal the state of the fallopian tubes in women at different phases of the menstrual cycle.
For the study, 2000 pairs of fallopian tubes obtained from the corpses of women who died from accidental causes and did not have pathology at the level of the reproductive and immune systems were used. The histological examination of the endometrium was performed. The microanatomical sections of the fallopian tubes were divided into three parts: the isthmus, the ampulla and the infundibulum. Histological sections were stained with standard methods. Variation-statistical processing of the results was carried out by conventional methods.
In the fallopian tubes during the studied periods of postnatal ontogenesis, diffuse lymphoid tissue is constantly present, in which under the influence of hormonal changes there are variously directed changes in the factors of innate immunity. The structure possesses the following characteristic features: it is rich in lymphoid cells the ratio of which changes not only with age but under the influence of external factors.
The hormonal activity causes changes in the lymphoid structures of the mucous membrane of the fallopian tubes, which leads to a decrease in the immune response and causes atrophic changes in the mucous membrane of the female genital organs.
The materials of the article can be useful for the studies developing complex problematics of correlation changes in the fallopian tube in case of its pathology within the genital tract.